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Arch Neurol. 2007 Oct;64(10):1482-7.

Reduced hippocampal functional connectivity in Alzheimer disease.

Author information

  • 1Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9127, USA. Greg.Allen@UTSouthwestern.edu

Abstract

OBJECTIVE:

To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease.

DESIGN:

Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain.

PARTICIPANTS:

Eight patients with probable Alzheimer disease and 8 healthy volunteers.

RESULTS:

Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes.

CONCLUSION:

These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.

PMID:
17923631
[PubMed - indexed for MEDLINE]
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