Cell. 2007 Oct 5;131(1):25-8.

miRNAs get an early start on translational silencing.

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Munich Center for integrated protein science (CiPSM), Laboratory of RNA Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany. meister@biochem.mpg.de

Abstract

MicroRNAs (miRNAs) control gene expression by regulating mRNA stability and translation. Using cell-free in vitro systems, several labs have recently reported insights into the molecular mechanisms underlying miRNA-guided translational repression (Kiriakidou et al., 2007; Mathonnet et al., 2007; Thermann and Hentze, 2007; Wakiyama et al., 2007). These new findings indicate that miRNAs inhibit translation at early steps of initiation.

PMID:: 17923084; [PubMed - indexed for MEDLINE]

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