Abstract
Neural salient serine/arginine-rich protein 1 (NSSR1) expression has been found in mouse cerebral neurons, cerebellar Purkinje cells, pyramidal neurons and granule cells of dentate gyrus and regulates the pre-mRNA splicing of genes important for neural functions. In this study, we demonstrated that NSSR1 is expressed in rat retina and extensively distributed in the outer and inner plexiform layers. Double staining experiments showed that NSSR1 distributed mainly in ON-type bipolar cells and localized in the dendrites, somata and axon terminals. The result suggests that NSSR1 may play important roles in retinal function, possibly via regulating the neural-specific alternative splicing of genes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibody Specificity
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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Dendrites / metabolism
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Dendrites / ultrastructure
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Eye Proteins / genetics
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Eye Proteins / metabolism*
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Fluorescent Antibody Technique
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Immunohistochemistry
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Male
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Neoplasm Proteins / genetics
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Neoplasm Proteins / metabolism
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Neurons / cytology
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Neurons / metabolism*
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Presynaptic Terminals / metabolism
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Presynaptic Terminals / ultrastructure
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RNA Splicing / physiology
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / metabolism*
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Rats
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Rats, Sprague-Dawley
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Repressor Proteins / genetics
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Repressor Proteins / metabolism
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Retina / cytology
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Retina / metabolism*
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Retinal Bipolar Cells / cytology
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Retinal Bipolar Cells / metabolism
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Retinal Ganglion Cells
Substances
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Cell Cycle Proteins
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Eye Proteins
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Fusip1 protein, mouse
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Neoplasm Proteins
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RNA-Binding Proteins
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Repressor Proteins