Am J Clin Nutr. 2007 Oct;86(4):899-906.

Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.

Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, Gersch MS, Benner S, Sánchez-Lozada LG.

Source

Division of Nephrology and Department of Medicine, University of Florida, Gainesville, FL, USA. johnsrj@medicine.ufl.edu

Abstract

Currently, we are experiencing an epidemic of cardiorenal disease characterized by increasing rates of obesity, hypertension, the metabolic syndrome, type 2 diabetes, and kidney disease. Whereas excessive caloric intake and physical inactivity are likely important factors driving the obesity epidemic, it is important to consider additional mechanisms. We revisit an old hypothesis that sugar, particularly excessive fructose intake, has a critical role in the epidemic of cardiorenal disease. We also present evidence that the unique ability of fructose to induce an increase in uric acid may be a major mechanism by which fructose can cause cardiorenal disease. Finally, we suggest that high intakes of fructose in African Americans may explain their greater predisposition to develop cardiorenal disease, and we provide a list of testable predictions to evaluate this hypothesis.

Comment in

Am J Clin Nutr. 2008 Apr;87(4):1062; author reply 1063-5.

PMID:: 17921363; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

FRUCTOSE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Review Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? [Endocr Rev. 2009]
Review Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
Johnson RJ, Perez-Pozo SE, Sautin YY, Manitius J, Sanchez-Lozada LG, Feig DI, Shafiu M, Segal M, Glassock RJ, Shimada M, et al. Endocr Rev. 2009 Feb; 30(1):96-116. Epub 2009 Jan 16.
Review Role of uric acid in hypertension, renal disease, and metabolic syndrome. [Cleve Clin J Med. 2006]
Review Role of uric acid in hypertension, renal disease, and metabolic syndrome.
Heinig M, Johnson RJ. Cleve Clin J Med. 2006 Dec; 73(12):1059-64.
Review Dietary fructose and hypertension. [Curr Hypertens Rep. 2011]
Review Dietary fructose and hypertension.
Madero M, Perez-Pozo SE, Jalal D, Johnson RJ, Sánchez-Lozada LG. Curr Hypertens Rep. 2011 Feb; 13(1):29-35.
Review The role of high-fructose corn syrup in metabolic syndrome and hypertension. [Curr Hypertens Rep. 2010]
Review The role of high-fructose corn syrup in metabolic syndrome and hypertension.
Ferder L, Ferder MD, Inserra F. Curr Hypertens Rep. 2010 Apr; 12(2):105-12.
Just a spoonful of sugar helps the blood pressure go up. [Expert Rev Cardiovasc Ther. 2010]
Just a spoonful of sugar helps the blood pressure go up.
Nguyen S, Lustig RH. Expert Rev Cardiovasc Ther. 2010 Nov; 8(11):1497-9.

See reviews... See all...

Cited by 44 PubMed Central articles

The Role of Overweight and Obesity in the Cardiorenal Syndrome. [Cardiorenal Med. 2011]
The Role of Overweight and Obesity in the Cardiorenal Syndrome.
Sowers JR, Whaley-Connell A, Hayden MR. Cardiorenal Med. 2011 Jan; 1(1):5-12. Epub 2011 Jan 17.
Starches, sugars and obesity. [Nutrients. 2011]
Starches, sugars and obesity.
Aller EE, Abete I, Astrup A, Martinez JA, van Baak MA. Nutrients. 2011 Mar; 3(3):341-69. Epub 2011 Mar 14.
Sugar sweetened beverage consumption by Australian children: implications for public health strategy. [BMC Public Health. 2011]
Sugar sweetened beverage consumption by Australian children: implications for public health strategy.
Hafekost K, Mitrou F, Lawrence D, Zubrick SR. BMC Public Health. 2011 Dec 22; 11:950. Epub 2011 Dec 22.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Potential role of sugar (fructose) in the epidemic of hypertension, obesity and ...
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
Am J Clin Nutr. 2007 Oct ;86(4):899-906.

PubMed
IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 M...
IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation.
Am J Physiol Heart Circ Physiol. 2007 Dec ;293(6):H3356-65. Epub 2007 Oct 5 .

PubMed
A conserved glycine residue of trimeric autotransporter domains plays a key role...
A conserved glycine residue of trimeric autotransporter domains plays a key role in Yersinia adhesin A autotransport.
J Bacteriol. 2007 Dec ;189(24):9011-9. Epub 2007 Oct 5 .

PubMed
N-(3-hydroxyhexanoyl)-l-homoserine lactone is the biologically relevant quormone...
N-(3-hydroxyhexanoyl)-l-homoserine lactone is the biologically relevant quormone that regulates the phz operon of Pseudomonas chlororaphis strain 30-84.
Appl Environ Microbiol. 2007 Nov ;73(22):7443-55. Epub 2007 Oct 5 .

PubMed
Comparing active and repressed expression states of genes controlled by the Poly...
Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins.
Proc Natl Acad Sci U S A. 2007 Oct 16 ;104(42):16615-20. Epub 2007 Oct 5 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: