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Eur Neurol. 2008;59(1-2):24-30. Epub 2007 Oct 4.

Activation of the prefrontal cortex during the wisconsin card sorting test (Keio Version) as measured by two-channel near-infrared spectroscopy in patients with traumatic brain injury.

Author information

  • 1Department of Rehabilitation Medicine, Jikei University School of Medicine, Tokyo, Japan. keiman@jikei.ac.jp


To investigate brain activation in the prefrontal cortex (PFC) during the Wisconsin Card Sorting Test (Keio Version) (KWCST), we examined changes in total hemoglobin volume (THV) in 8 patients with traumatic brain injury (TBI) and 20 healthy control subjects using two-channel near-infrared spectroscopy. As a result, average THV in the right PFC during KWCST in TBI patients (-0.131 +/- 0.127) was significantly lower than in control subjects (0.016 +/- 0.135) (2 x 3 ANOVA; p < 0.05). These results demonstrated that the TBI patients had lower circulation of hemoglobin in the right PFC during the KWCST than the control subjects.

(c) 2007 S. Karger AG, Basel

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