Mol Neurobiol. 2007 Jun;35(3):245-54.

Roles of transient receptor potential vanilloid subtype 1 and cannabinoid type 1 receptors in the brain: neuroprotection versus neurotoxicity.

Kim SR, Chung YC, Chung ES, Park KW, Won SY, Bok E, Park ES, Jin BK.

Source

Brain Disease Research Center, Ajou University School of Medicine, Suwon, 443-479, South Korea.

Abstract

Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases. Cannabinoid type 1 (CB1) receptor belongs to the G protein-coupled receptor superfamily and is activated by cannabinoids such as AEA and exogenous Delta-9-tetrahydrocannabinol (THC). TRPV1 and CB1 receptors are widely expressed in the brain and play many significant roles in various brain regions; however, the issue of whether TRPV1 or CB1 receptors mediate neuroprotection or neurotoxicity remains controversial. Furthermore, functional crosstalk between these two receptors has been recently reported. It is therefore timely to review current knowledge regarding the functions of these two receptors and to consider new directions of investigation on their roles in the brain.

PMID:: 17917113; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

CAPSAICIN - HSDB

Supplemental Content

Save items

Related citations in PubMed

The endogenous cannabinoid anandamide inhibits transient receptor potential vanilloid type 1 receptor-mediated currents in rat cultured primary sensory neurons. [Acta Physiol Hung. 2010]
The endogenous cannabinoid anandamide inhibits transient receptor potential vanilloid type 1 receptor-mediated currents in rat cultured primary sensory neurons.
Sántha P, Jenes A, Somogyi C, Nagy I. Acta Physiol Hung. 2010 Jun; 97(2):149-58.
Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro. [J Neurosci. 2005]
Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro.
Kim SR, Lee DY, Chung ES, Oh UT, Kim SU, Jin BK. J Neurosci. 2005 Jan 19; 25(3):662-71.
Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases. [J Neurosci. 2003]
Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases.
Veldhuis WB, van der Stelt M, Wadman MW, van Zadelhoff G, Maccarrone M, Fezza F, Veldink GA, Vliegenthart JF, Bär PR, Nicolay K, et al. J Neurosci. 2003 May 15; 23(10):4127-33.
Review Pharmacological actions of cannabinoids. [Handb Exp Pharmacol. 2005]
Review Pharmacological actions of cannabinoids.
Pertwee RG. Handb Exp Pharmacol. 2005; (168):1-51.
Review Anandamide and the vanilloid receptor (TRPV1). [Vitam Horm. 2009]
Review Anandamide and the vanilloid receptor (TRPV1).
Tóth A, Blumberg PM, Boczán J. Vitam Horm. 2009; 81:389-419.

See reviews... See all...

Cited by 3 PubMed Central articles

A putative 'pre-nervous' endocannabinoid system in early echinoderm development. [Dev Neurosci. 2010]
A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
Buznikov GA, Nikitina LA, Bezuglov VV, Francisco ME, Boysen G, Obispo-Peak IN, Peterson RE, Weiss ER, Schuel H, Temple BR, et al. Dev Neurosci. 2010 Mar; 32(1):1-18. Epub 2009 Nov 12.
Review Epoxyeicosanoid signaling in CNS function and disease. [Prostaglandins Other Lipid Med...]
Review Epoxyeicosanoid signaling in CNS function and disease.
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ. Prostaglandins Other Lipid Mediat. 2010 Apr; 91(3-4):68-84. Epub 2009 Jun 21.
Review Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia. [Trends Pharmacol Sci. 2009]
Review Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia.
Akopian AN, Ruparel NB, Jeske NA, Patwardhan A, Hargreaves KM. Trends Pharmacol Sci. 2009 Feb; 30(2):79-84. Epub 2008 Dec 11.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Roles of transient receptor potential vanilloid subtype 1 and cannabinoid type 1...
Roles of transient receptor potential vanilloid subtype 1 and cannabinoid type 1 receptors in the brain: neuroprotection versus neurotoxicity.
Mol Neurobiol. 2007 Jun ;35(3):245-54.

PubMed
Area socioeconomic status and childhood injury morbidity in New South Wales, Aus...
Area socioeconomic status and childhood injury morbidity in New South Wales, Australia.
Inj Prev. 2007 Oct ;13(5):322-7.

PubMed
Amateur boxing and risk of chronic traumatic brain injury: systematic review of ...
Amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies.
BMJ. 2007 Oct 20 ;335(7624):809. Epub 2007 Oct 4 .

PubMed
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without...
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.
Am J Respir Crit Care Med. 2008 Jan 1 ;177(1):56-65. Epub 2007 Oct 4 .

PubMed
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth...
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis.
Am J Respir Crit Care Med. 2008 Jan 1 ;177(1):82-90. Epub 2007 Oct 4 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Roles of transient receptor potential vanilloid subtype 1 and cannabinoid type 1 receptors in the brain: neuroprotection versus neurotoxicity.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information