Leuk Res. 2008 May;32(5):823-7. Epub 2007 Oct 29.

Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia.

Lai DW, Loughran TP Jr, Maciejewski JP, Sasu S, Song SX, Epling-Burnette PK, Paquette RL.

Source

VA Greater Los Angeles Health Care System, Los Angeles, CA 90095-1678, United States.

Abstract

Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia rarely occur concurrently. We report a case in which these disorders were associated with an occult large granular lymphocyte leukemia. The peripheral blood cytopenias improved after glucocorticoids and intravenous immunoglobulin were administered, and response was maintained with cyclosporine. Large granular lymphocyte leukemia should be suspected in the setting of unexplained bone marrow failure.

PMID:: 17915315; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Platelet Disorders - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Long-term responses and outcomes following immunosuppressive therapy in large granular lymphocyte leukemia-associated pure red cell aplasia: a Nationwide Cohort Study in Japan for the PRCA Collaborative Study Group. [Haematologica. 2008]
Long-term responses and outcomes following immunosuppressive therapy in large granular lymphocyte leukemia-associated pure red cell aplasia: a Nationwide Cohort Study in Japan for the PRCA Collaborative Study Group.
Fujishima N, Sawada K, Hirokawa M, Oshimi K, Sugimoto K, Matsuda A, Teramura M, Karasawa M, Arai A, Yonemura Y, et al. Haematologica. 2008 Oct; 93(10):1555-9. Epub 2008 Jul 18.
Large granular lymphocyte leukemia presenting with both amegakaryocytic thrombocytopenic purpura and pure red cell aplasia: clinical course and response to immunosuppressive therapy. [Am J Hematol. 1995]
Large granular lymphocyte leukemia presenting with both amegakaryocytic thrombocytopenic purpura and pure red cell aplasia: clinical course and response to immunosuppressive therapy.
Kouides PA, Rowe JM. Am J Hematol. 1995 Jul; 49(3):232-6.
[The clinical characteristics of T cell large granular lymphocyte leukemia associated with pure red cell aplasia]. [Zhonghua Xue Ye Xue Za Zhi. 2008]
[The clinical characteristics of T cell large granular lymphocyte leukemia associated with pure red cell aplasia].
Zhou K, Wang HJ, Zhang L, Li HQ, Yang DL, Yan ZS, Jing LP, Wu YH, Chu YL, Zhang FK. Zhonghua Xue Ye Xue Za Zhi. 2008 May; 29(5):312-5.
Review [Pathophysiology and treatment of large granular lymphocyte leukemia-associated pure red cell aplasia]. [Rinsho Ketsueki. 2010]
Review [Pathophysiology and treatment of large granular lymphocyte leukemia-associated pure red cell aplasia].
Fujishima N. Rinsho Ketsueki. 2010 Aug; 51(8):589-96.
Review [T-cell large granular lymphocytic leukemia associated with pure red cell aplasia, successfully treated with cyclophosphamide]. [Orv Hetil. 1997]
Review [T-cell large granular lymphocytic leukemia associated with pure red cell aplasia, successfully treated with cyclophosphamide].
Mátrai Z, Lelkes G, Milosevits J, Páldiné HP, Pecze K. Orv Hetil. 1997 Aug 17; 138(33):2075-80.

See reviews... See all...

Cited by 2 PubMed Central articles

Review The ITP syndrome: pathogenic and clinical diversity. [Blood. 2009]
Review The ITP syndrome: pathogenic and clinical diversity.
Cines DB, Bussel JB, Liebman HA, Luning Prak ET. Blood. 2009 Jun 25; 113(26):6511-21. Epub 2009 Apr 24.
Review Pathobiology of secondary immune thrombocytopenia. [Semin Hematol. 2009]
Review Pathobiology of secondary immune thrombocytopenia.
Cines DB, Liebman H, Stasi R. Semin Hematol. 2009 Jan; 46(1 Suppl 2):S2-14.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated w...
Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia.
Leuk Res. 2008 May ;32(5):823-7. Epub 2007 Oct 29 .

PubMed
Short-term exposure to air pollution and inflammation-sensitive biomarkers.
Short-term exposure to air pollution and inflammation-sensitive biomarkers.
Environ Res. 2008 Jan ;106(1):51-61. Epub 2007 Oct 29 .

PubMed
Treatment of patients comorbid for addiction and other psychiatric disorders.
Treatment of patients comorbid for addiction and other psychiatric disorders.
Curr Psychiatry Rep. 2007 Oct ;9(5):374-80.

PubMed
Phylogeography and domestication of Indian river buffalo.
Phylogeography and domestication of Indian river buffalo.
BMC Evol Biol. 2007 Oct 4 ;7:186.

PubMed
Diagnostic specificity and nonspecificity in the dimensions of preschool psychop...
Diagnostic specificity and nonspecificity in the dimensions of preschool psychopathology.
J Child Psychol Psychiatry. 2007 Oct ;48(10):1005-13.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: