Curr Opin Genet Dev. 2007 Oct;17(5):408-14. Epub 2007 Oct 24.

The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1.

Galande S, Purbey PK, Notani D, Kumar PP.

Source

National Centre for Cell Science, Ganeshkhind, Pune 411007, India. sanjeev@nccs.res.in

Abstract

Compartmentalized distribution of functional components is a hallmark of the eukaryotic nucleus. Technological advances in recent years have provided unprecedented insights into the role of chromatin organization and interactions of various structural-functional components toward gene regulation. SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation. Studies in recent years have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli. SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances. Silencing of SATB1 mimics the effects of IFNgamma treatment on chromatin loop architecture of the MHC class-I locus and altered expression of genes within the locus. At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin.

PMID:: 17913490; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

Wellcome Trust/United Kingdom

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Related citations

Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. [Nat Cell Biol. 2007]
Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus.
Kumar PP, Bischof O, Purbey PK, Notani D, Urlaub H, Dejean A, Galande S. Nat Cell Biol. 2007 Jan; 9(1):45-56. Epub 2006 Dec 17.
SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. [Nat Genet. 2006]
SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes.
Cai S, Lee CC, Kohwi-Shigematsu T. Nat Genet. 2006 Nov; 38(11):1278-88. Epub 2006 Oct 22.
SATB1 targets chromatin remodelling to regulate genes over long distances. [Nature. 2002]
SATB1 targets chromatin remodelling to regulate genes over long distances.
Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T. Nature. 2002 Oct 10; 419(6907):641-5.
Review MARs and MARBPs: key modulators of gene regulation and disease manifestation. [Subcell Biochem. 2007]
Review MARs and MARBPs: key modulators of gene regulation and disease manifestation.
Chattopadhyay S, Pavithra L. Subcell Biochem. 2007; 41:213-30.
Review Chromosome territories, interchromatin domain compartment, and nuclear matrix: an integrated view of the functional nuclear architecture. [Crit Rev Eukaryot Gene Expr. 2000]
Review Chromosome territories, interchromatin domain compartment, and nuclear matrix: an integrated view of the functional nuclear architecture.
Cremer T, Kreth G, Koester H, Fink RH, Heintzmann R, Cremer M, Solovei I, Zink D, Cremer C. Crit Rev Eukaryot Gene Expr. 2000; 10(2):179-212.

See reviews... See all...

Cited by 20 PubMed Central articles

Enhanced chromatin accessibility and recruitment of JUNB mediate the sustained IL-4 expression in NFAT1 deficient T helper 2 cells. [PLoS One. 2011]
Enhanced chromatin accessibility and recruitment of JUNB mediate the sustained IL-4 expression in NFAT1 deficient T helper 2 cells.
Son JS, Chae CS, Hwang JS, Park ZY, Im SH. PLoS One. 2011; 6(7):e22042. Epub 2011 Jul 25.
Repulsive forces between looping chromosomes induce entropy-driven segregation. [PLoS One. 2011]
Repulsive forces between looping chromosomes induce entropy-driven segregation.
Bohn M, Heermann DW. PLoS One. 2011 Jan 4; 6(1):e14428. Epub 2011 Jan 4.
The L2a element is a mouse CD8 silencer that interacts with MAR-binding proteins SATB1 and CDP. [Mol Immunol. 2010]
The L2a element is a mouse CD8 silencer that interacts with MAR-binding proteins SATB1 and CDP.
Yao X, Nie H, Rojas IC, Harriss JV, Maika SD, Gottlieb PD, Rathbun G, Tucker PW. Mol Immunol. 2010 Nov-Dec; 48(1-3):153-63. Epub 2010 Sep 29.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The third dimension of gene regulation: organization of dynamic chromatin loopsc...
The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1.
Curr Opin Genet Dev. 2007 Oct ;17(5):408-14. Epub 2007 Oct 24 .

PubMed
The interferon regulatory factor, IRF5, is a central mediator of toll-like recep...
The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
J Biol Chem. 2005 Apr 29 ;280(17):17005-12. Epub 2005 Jan 28 .

PubMed
Statin drugs and risk of advanced prostate cancer.
Statin drugs and risk of advanced prostate cancer.
J Natl Cancer Inst. 2006 Dec 20 ;98(24):1819-25.

PubMed
Multiple signals regulate phospholipase CBeta3 in human myometrial cells.
Multiple signals regulate phospholipase CBeta3 in human myometrial cells.
Biol Reprod. 2008 Jun ;78(6):1007-17. Epub 2008 Mar 5 .

PubMed
Apoptotic actions of p53 require transcriptional activation of PUMA and do not i...
Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons.
J Neurosci. 2007 Nov 7 ;27(45):12198-210.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: