Display Settings:


Send to:

Choose Destination
Org Biomol Chem. 2007 Oct 21;5(20):3340-6. Epub 2007 Sep 14.

Efficient asymmetric hydrogenation of olefins with hydrazine-derived diphosphoramidites.

Author information

  • 1Laboratoire de Chimie Inorganique Mol√©culaire, Institut de Chimie, UMR 7177 CNRS and Universit√© Louis Pasteur, 1 rue Blaise Pascal, F-67008, Strasbourg, Cedex, France.


Enantiopure, BINOL-derived diphosphoramidites built upon an achiral hydrazine spacer are efficient ligands for the hydrogenation of 2-(acetylamino)-3-(aryl)-propenoic methyl esters. The activity and enantioselectivity of the hydrazine derivatives were shown to be markedly influenced by the nature of the two NR substituents, symmetrical but bulky R groups leading to the best results. A diphosphosphoramidite obtained from (t)BuHNNH(t)Bu resulted in ee's as high as 95%. The present results contradict previous reports on "short" diphosphoramidites.

[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry
    Loading ...
    Write to the Help Desk