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Nat Rev Genet. 2007 Nov;8(11):829-33.

Histone lysine demethylases: emerging roles in development, physiology and disease.

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  • 1Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.


The discovery of an increasing number of histone demethylases has highlighted the dynamic nature of the regulation of histone methylation, a key chromatin modification that is involved in eukaryotic genome and gene regulation. A flurry of recent studies has offered glimpses into the specific biological roles of these enzymes and their potential connections to human diseases. These advances have also catalysed a resurgence of interest in epigenetic regulators as potential therapeutic targets.

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