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Nat Genet. 2007 Nov;39(11):1318-20. Epub 2007 Sep 30.

Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs.

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  • 1Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences (SLU), Biomedical Centre, Box 597, SE-751 24 Uppsala, Sweden.

Abstract

The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.

PMID:
17906623
[PubMed - indexed for MEDLINE]
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