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Curr Opin Genet Dev. 2007 Oct;17(5):435-42. Epub 2007 Oct 1.

Mobility and immobility of chromatin in transcription and genome stability.

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  • 1National Cancer Institute, NIH, Bethesda, MD 20892, United States.

Abstract

Chromatin is increasingly recognized as a highly dynamic entity. Chromosome sites in lower and higher eukaryotes undergo frequent, rapid, and constrained local motion and occasional slow, long-range movements. Recent observations have revealed some of the functional relevance of chromatin mobility. Paradoxically, both the mobility and immobility of chromatin appear to have functional consequences: Local diffusional motion of chromatin is important in gene regulation, but global chromatin immobility plays a key role in maintenance of genomic stability.

PMID:
17905579
[PubMed - indexed for MEDLINE]
PMCID:
PMC2118061
Free PMC Article

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