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Pathol Biol (Paris). 2007 Nov;55(8-9):460-4. Epub 2007 Oct 1.

[Cranberry (Vaccinium macrocarpon) and urinary tract infections: study model and review of literature].

[Article in French]

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  • 1Institut national de la santé et de la recherche médicale, ESPRI 26, université de Montpellier-I, UFR de médecine, avenue Kennedy, CS83021, 30908 Nîmes cedex 02, France. jean-philippe.lavigne@univ-montp1.fr


Cranberries (Vaccinium macrocarpon) have long been the focus of interest for their beneficial effects in preventing urinary tract infections. Among cranberry compounds, a group of proanthocyanidins (PACs) with A-type linkages were isolated which exhibit bacterial anti-adhesion activity against uropathogenic Escherichia coli strains. These PAC inhibit P-fimbriae synthesis and induce a bacterial deformation. This activity was demonstrated on both antibiotic susceptible and resistant bacteria. This review focused on the last discoveries in the knowledge of cranberry effects.

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