Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Obstet Gynecol. 2007 Oct;197(4):363.e1-5.

Placental angiogenesis markers sFlt-1 and PlGF: response to cigarette smoke.

Author information

  • 1Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, IL 60612, USA. rmehenda@uic.edu

Abstract

OBJECTIVE:

Excess soluble vascular endothelial growth factor receptor, fms-like tyrosine kinase-1 (sFlt-1), and reduced placental growth factor (PlGF) mediate the genesis of preeclampsia. Cigarette smoking reduces the risk of preeclampsia. We hypothesized that placental secretion of sFlt-1 and PlGF was affected by exposure to cigarette smoke extract.

STUDY DESIGN:

Term placental villous explants were cultured with cigarette smoke extract. Media were analyzed for sFlt-1 and PlGF. Apoptosis was measured by TUNEL staining. Results are reported as sFlt-1 or PlGF picogram/milliliter/milligram wet weight of explant.

RESULTS:

Exposure to cigarette smoke extract reduced secretion of sFlt-1 in a dose-dependent manner. There was no difference in apoptosis. In contrast with sFlt-1, PlGF did not decline when incubated with cigarette smoke extract.

CONCLUSION:

Exposure of placental villous explants to cigarette smoke extract results in a proangiogenic state with reduced sFlt-1 and relative abundance of PlGF. This is the reverse of changes that are seen in preeclampsia and may explain the reduction of preeclampsia in smokers.

PMID:
17904960
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk