Acta Virol. 2007;51(2):101-8.

Influenza a virus PB1-F2 protein.

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Institute of Virology, Slovak Academy of Sciences, 84505 Bratislava, Slovak Republic.

Abstract

PB1-F2 protein (PB1-F2) is encoded by the alternative (+1) ORF in the PB1 gene of influenza A viruses (IAVs). This protein has a number of unique features, namely its absence from some animal IAV isolates, variable expression in individual infected cells, rapid proteasome-dependent degradation, mitochondrial localization, and apoptotic or pro-apoptotic properties. Localization of PB1-F2 to mitochondria is mediated via C-terminal basic amphipathic alpha-helix. PB1-F2 affects apoptosis and may contribute to the pathogenicity and lethality of IAVs. Sequence analysis showed that, in addition to the strains with an ORF for full-length PB1-F2, there are some with an ORF for different truncated forms of PB1-F2. Several other viruses encode proteins with structure and function similar to PB1-F2 of IAVs.

PMID:: 17900216; [PubMed - indexed for MEDLINE]

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Cited by 1 PubMed Central article

Antibodies to PB1-F2 protein are induced in response to influenza A virus infection. [Arch Virol. 2009]
Antibodies to PB1-F2 protein are induced in response to influenza A virus infection.
Krejnusová I, Gocníková H, Bystrická M, Blaskovicová H, Poláková K, Yewdell J, Bennink J, Russ G. Arch Virol. 2009; 154(10):1599-604. Epub 2009 Aug 12.

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