Org Lett. 2007 Oct 25;9(22):4475-7. Epub 2007 Sep 28.

Novel proton acceptor immonium-type coupling reagents: application in solution and solid-phase peptide synthesis.

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Institute for Research in Biomedicine, Barcelona Science Park, Josep Samitier 1, 08028-Barcelona, Spain. aymanel_faham@hotmail.com

Abstract

A novel proton acceptor coupling reagent shows superiority to those described previously. The oxygen in the carbocation moiety confers more solubility to the reagent. Furthermore, it enhances coupling yields and decreases racemization, allowing the use of 1 equiv of base.

PMID:: 17900195; [PubMed - indexed for MEDLINE]

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