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    Rheumatol Int. 2008 Feb;28(4):355-60. Epub 2007 Sep 26.

    The -844 G/A PAI-1 polymorphism is associated with mRNA expression in rheumatoid arthritis.

    Torres-Carrillo NM, Torres-Carrillo N, Vázquez-Del Mercado M, Delgado-Rizo V, Oregón-Romero E, Parra-Rojas I, Muñoz-Valle JF.

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    Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Col. Independencia, Guadalajara, Jalisco 44340, Mexico.

    Abstract

    We assessed whether the -844 G/A polymorphism and mRNA expression of plasminogen activator inhibitor 1 (PAI-1) gene are associated with rheumatoid arthritis (RA). Demographic data, hematological, biochemical parameters, disease activity-disability indexes, -844 G/A genotypes and mRNA expression levels of the PAI-1 gene were determined in 50 RA patients and 50 healthy subjects (HS). Non-significant differences in genotype and allele frequencies related to -844 G/A polymorphism in RA versus HS, were found. High mRNA expression of the PAI-1 gene, was demonstrated in RA versus HS (P < 0.05). In addition, A/A genotype carriers showed increase of PAI-1 mRNA expression (3.1-fold) respect to G/G and G/A genotypes in RA patients (P < 0.05). Our finding suggest an association of A/A -844 PAI-1 genotype with high PAI-1 mRNA expression in RA patients.

    PMID:
    17899094
    [PubMed - indexed for MEDLINE]

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