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Clin Pharmacol Ther. 2007 Nov;82(5):591-4. Epub 2007 Sep 26.

Endocannabinoid system and cardiometabolic risk.

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  • 1General Cardiology & Coronary Care Unit Services, CCR ASCARDIO, Barquisimeto, Venezuela.


The increasing prevalence of overweight and obesity counteracts the favorable advances of risk factor management achieved for cardiovascular disease (CVD) prevention. Obese and overweight individuals are at increased risk for CVDs and diabetes mellitus, a risk pattern called "cardiometabolic risk." There is a growing interest concerning the role of the endocannabinoid system in energy metabolism and how blockade of cannabinoid receptors (CB(1)) may optimize fat distribution, insulin sensitivity, and blood lipids to improve cardiovascular risk profile.

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