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1: Otol Neurotol. 2007 Dec;28(8):1026-8. Links

Bacterial biofilms may explain chronicity in osteoradionecrosis of the temporal bone.

Nason R, Chole RA.

Department of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

OBJECTIVE: To identify biofilm formation within a case of temporal bone osteoradionecrosis. PATIENT: Single-case patient presenting with temporal bone osteoradionecrosis. INTERVENTION(S): Antibiotic therapy and then surgical debridement of the temporal bone. MAIN OUTCOME MEASURE(S): Histologic identification of biofilm formation within the affected temporal bone specimen. RESULTS: Positive identification of biofilm formation in multiple sections of the temporal bone specimen removed from a patient affected by osteoradionecrosis. CONCLUSION: This is the first evidence that temporal bone osteoradionecrosis involves biofilm formation. Such a pathogenic mechanism may explain the recalcitrance of this disease process and offer new strategies in formulating therapeutic interventions.

PMID: 17898674 [PubMed - indexed for MEDLINE]