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1: J Stroke Cerebrovasc Dis. 2000 Mar-Apr;9(2):89-90.Click here to read Links

Superior sagittal sinus thrombosis secondary to hyperthyroidism.

Dai A, Wasay M, Dubey N, Giglio P, Bakshi R.

Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA.

Superior sagittal sinus thrombosis (SSST) is associated with a variety of hypercoaguable states. Although coagulation disturbances are reported in hyperthyroidism, a direct link between hyperthyroidism and cerebral venous thrombosis is not established. We report a 39-year-old man who developed increased intracranial pressure, seizures, and rapid atrial fibrillation. Neuroimaging showed SSST, and laboratory studies were consistent with hyperthyroidism. No other causes of a hypercoaguable state were identified. Prompt treatment of his hyperthyroidism led to recanalization of the superior sagittal sinus and a full neurological recovery. Given the known effects of hyperthyroidism on factor VIII activity, we hypothesize that hyperthyroidism is an independent risk factor for SSST. A high index of suspicion for SSST is warranted in patients with hyperthyroidism and neurological symptoms. Furthermore, thyroid dysfunction should be excluded in patients with unexplained SSST.

PMID: 17895204 [PubMed]

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