Send to:

Choose Destination
See comment in PubMed Commons below
Int J Cancer. 2007 Dec 1;121(11):2373-80.

Inflammation and cancer: an ancient link with novel potentials.

Author information

  • 1Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA.


Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of the inflammatory response, e.g., cytokines, free radicals, prostaglandins and growth factors, can induce genetic and epigenetic changes including point mutations in tumor suppressor genes, DNA methylation and post-translational modifications, causing alterations in critical pathways responsible for maintaining the normal cellular homeostasis and leading to the development and progression of cancer. Recent discovery of an interaction between microRNAs and innate immunity during inflammation has further strengthened the association between inflammation and cancer.

(c) 2007 Wiley-Liss, Inc.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk