Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Clin Virol. 2007 Nov;40(3):207-13. Epub 2007 Sep 21.

Seroepidemiology of group I human coronaviruses in children.

Author information

  • 1Department of Pediatrics, Division of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

BACKGROUND:

Recently, several new human coronaviruses have been identified.

OBJECTIVES:

To define the seroepidemiology of group I human coronaviruses.

STUDY DESIGN:

A recombinant protein enzyme linked immunosorbent assay (ELISA) based on portions of the nucleocapsid protein of group I human coronaviruses was developed and was used to screen serum from 243 children and young adults.

RESULTS:

For HCoV-229E, the percentages of seropositive individuals were 57.1% for infants <2 months old; 38.9% for infants 2-3 months old; 4.7% for infants 4-5 months old; 42.9-50.0% for infants 6-12 months old; 34.8-62.5% for individuals 1-20 years old. For HCoV-NL63, the percentages of seropositive individuals were 45.2% for infants <2 months old; 11.1% for infants 2-3 months old; 4.7% for infants 4-5 months old; 28.6-40.0% for infants 6-12 months old; 25.0-70.3% for individuals 1-20 years old.

CONCLUSIONS:

Infection with these viruses is common in childhood though the prevalence of these viruses may vary from year to year.

PMID:
17889596
[PubMed - indexed for MEDLINE]
PMCID:
PMC2100388
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk