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J Pharm Biomed Anal. 2007 Nov 30;45(4):565-71. Epub 2007 Aug 15.

Comparison of extraction techniques for spray dried dispersion tablet formulations.

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  • 1Analytical Research and Development, Pfizer Global Research and Development, Eastern Pt. Road, Groton, CT 06340, USA.


Non-traditional sample preparation/extraction techniques that utilized the Caliper Life Sciences Tablet Processing Workstation II (TPW II), Microwave Assisted Extraction (MAE), and Accelerated Solvent Extraction (ASE) were evaluated for the extraction of Compound A from a 50 mgA, 15% Spray Dried Dispersion (SDD) immediate released (IR) tablet formulation. The TPW II consistently provided complete recoveries with very short preparation/extraction times (approximately 30 min). MAE also provided complete recovery of the API from the tablet formulation, but required approximately twice the extraction time, while ASE provided the lowest recovery of the three non-traditional techniques. The sample preparation/extraction efficiencies of the three non-traditional techniques were compared to that of the 5.5 h long manual method.

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