J Nat Prod. 2007 Oct;70(10):1632-5. Epub 2007 Sep 22.

Macrolactins O-R, glycosylated 24-membered lactones from Bacillus sp. AH159-1.

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Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon 305-806, Republic of Korea.

Abstract

In the course of screening for inhibitors of Staphylococcus aureus peptide deformylase, four new glycosylated macrolactin compounds, macrolactins O ( 1), P ( 2), Q ( 3), and R ( 4), along with the known macrolactins B ( 5) and C ( 6), have been isolated from the liquid cultures of Bacillus sp. AH159-1. The structures of compounds 1- 4 were assigned on the basis of MS and NMR data. They inhibited S. aureus peptide deformylase and also showed antibacterial activity against Escherichia coli and Staphylococcus aureus.

PMID:: 17887720; [PubMed - indexed for MEDLINE]

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