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Best Pract Res Clin Obstet Gynaecol. 2008 Apr;22(2):407-21. Epub 2007 Sep 19.

Hormonal therapies and gynaecological cancers.

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  • 1Mercy Hospital for Women, Heidelberg, Victoria 3084, Australia. AGarrett@mercy.com.au


Hormonal therapy has an established place in the management of women with gynaecological malignancies, including first-line therapy for recurrent receptor-positive endometrial cancer and low-grade stromal sarcoma. There is no place for adjuvant hormonal treatment of these cancers after primary surgery. Primary treatment with either oral or intra-uterine progestagens to preserve fertility in younger women with endometrial carcinoma is effective in about 70% of cases. Response rates to tamoxifen in advanced/recurrent ovarian cancers approximates 10%. To the authors' knowledge, no studies that reasonably compare different progestagens, different routes of therapy, different doses and different hormonal preparations have been published.

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