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Chem Biol. 2007 Sep;14(9):974-5.

An "orphan" finds a home in NSC regulation.

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  • 1Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.


Small molecules that can alter stem cell fate are of immense biological and therapeutic values. In this issue of Chemistry & Biology, Saxe and colleagues report a chemical genetic screen that identified an orphan ligand, P-Ser, which can modulate neural stem/progenitor cell fate.

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