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Bioorg Med Chem Lett. 2007 Nov 15;17(22):6206-11. Epub 2007 Sep 8.

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Author information

  • 1Novartis Institutes for Biomedical Research, Neuroscience, Novartis Pharma A.G., Basel, Switzerland. sebastien.2.guery@gsk.com

Abstract

The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABA(B) receptors is presented.

PMID:
17884493
[PubMed - indexed for MEDLINE]
PMCID:
PMC2278029
Free PMC Article

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