Metabolism. 2007 Oct;56(10):1402-4.

Lack of evident atherosclerosis despite multiple risk factors in glycogen storage disease type 1a with hyperadiponectinemia.

Tamaki M, Tamura Y, Ogihara T, Shimizu T, Uchino H, Hirose T, Kawamori R, Watada H.

Source

Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.

Abstract

We report a 60-year-old Japanese patient with glycogen storage disease type 1a (GSD1a) who was thoroughly evaluated for risk factors of atherosclerosis. As often observed in patients with GSD1a, this patient has multiple risk factors for atherosclerosis including hyperlipidemia, hypertension, glucose intolerance with insulin resistance, and chronic kidney disease. However, she lacked clinically evident atherosclerosis as generally observed in GSD1a patients. Unexpectedly, this patient had marked hyperadiponectinemia (27.6 microg/mL; reference range, 4.1-18.9 microg/mL) with increase in the ratio of high-molecular weight to total adiponectin. Although the reason for the hyperadiponectinemia was not clear, at least it seemed to protect against enhanced atherosclerogenesis otherwise promoted by a battery of risk factors. Although further studies are needed, hyperadiponectinemia in addition to hypoinsulinemia might explain at least in part the lack of evident atherosclerosis in patients with GSD1a.

PMID:: 17884452; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Case Reports

MeSH Terms

Substances

Adiponectin

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Related citations

Radical trapping in glycogen storage disease 1a. [Eur J Pediatr. 2002]
Radical trapping in glycogen storage disease 1a.
Wittenstein B, Klein M, Finckh B, Ullrich K, Kohlschütter A. Eur J Pediatr. 2002 Oct; 161 Suppl 1:S70-4. Epub 2002 Sep 19.
[Leptin to adiponectin ratio, as an index of insulin resistance and atherosclerosis development]. [Przegl Lek. 2008]
[Leptin to adiponectin ratio, as an index of insulin resistance and atherosclerosis development].
Kieć-Klimczak M, Malczewska-Malec M, Huszno B. Przegl Lek. 2008; 65(12):844-9.
Case report: Hepatocellular carcinoma in type 1a glycogen storage disease with identification of a glucose-6-phosphatase gene mutation in one family. [J Gastroenterol Hepatol. 1999]
Case report: Hepatocellular carcinoma in type 1a glycogen storage disease with identification of a glucose-6-phosphatase gene mutation in one family.
Nakamura T, Ozawa T, Kawasaki T, Yasumi K, Wang DY, Kitagawa M, Takehira Y, Tamakoshi K, Yamada M, Kida H, et al. J Gastroenterol Hepatol. 1999 Jun; 14(6):553-8.
Review Glucose-6-phosphate: a key compound in glycogenosis I and favism leading to hyper- or hypolipidaemia. [Eur J Pediatr. 1993]
Review Glucose-6-phosphate: a key compound in glycogenosis I and favism leading to hyper- or hypolipidaemia.
Schmitz G, Hohage H, Ullrich K. Eur J Pediatr. 1993; 152 Suppl 1:S77-84.
Review Adiponectin in chronic kidney disease has an opposite impact on protein-energy wasting and cardiovascular risk: two sides of the same coin. [Clin Nephrol. 2009]
Review Adiponectin in chronic kidney disease has an opposite impact on protein-energy wasting and cardiovascular risk: two sides of the same coin.
Park SH, Carrero JJ, Lindholm B, Stenvinkel P. Clin Nephrol. 2009 Aug; 72(2):87-96.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Lack of evident atherosclerosis despite multiple risk factors in glycogen storag...
Lack of evident atherosclerosis despite multiple risk factors in glycogen storage disease type 1a with hyperadiponectinemia.
Metabolism. 2007 Oct ;56(10):1402-4.

PubMed
A ketogenic diet impairs energy and glucose homeostasis by the attenuation of hy...
A ketogenic diet impairs energy and glucose homeostasis by the attenuation of hypothalamic leptin signaling and hepatic insulin signaling in a rat model of non-obese type 2 diabetes.
Exp Biol Med (Maywood). 2011 Feb ;236(2):194-204.

PubMed
Effects of traditional and western environments on prevalence of type 2 diabetes...
Effects of traditional and western environments on prevalence of type 2 diabetes in Pima Indians in Mexico and the U.S.
Diabetes Care. 2006 Aug ;29(8):1866-71.

PubMed
Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentratio...
Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects.
Am J Clin Nutr. 2009 Sep ;90(3):485-92. Epub 2009 Jul 29 .

PubMed
Higher fasting serum insulin is associated with increased resting energy expendi...
Higher fasting serum insulin is associated with increased resting energy expenditure in nondiabetic schizophrenia patients.
Biol Psychiatry. 2006 Dec 15 ;60(12):1372-7. Epub 2006 Aug 22 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: