J Neuroimmunol. 2007 Oct;190(1-2):170-6. Epub 2007 Sep 19.

TRAIL, CXCL10 and CCL2 plasma levels during long-term Interferon-beta treatment of patients with multiple sclerosis correlate with flu-like adverse effects but do not predict therapeutic response.

Buttmann M, Merzyn C, Hofstetter HH, Rieckmann P.

Source

Department of Neurology, Julius-Maximilians-University, Josef-Schneider-Strasse 11, Würzburg, Germany. m.buttmann@uni-wuerzburg.de

Abstract

High serum levels of soluble TRAIL (sTRAIL) before or during the first year of Interferon-beta (IFN-beta) therapy were shown to predict an individual therapeutic response of patients with relapsing-remitting multiple sclerosis (RRMS). Here, we investigated whether sTRAIL plasma levels during long-term IFN-beta treatment correlate with future therapeutic response or adverse effects of treatment. Postinjection short-time bursts of sTRAIL were associated with flu-like symptoms and IP-10/CXCL10 as well as MCP-1/CCL2 induction, and were detected after up to 6 years of continuous IFN-beta therapy. However, neither sTRAIL nor chemokine levels allowed prediction of one- and two-year clinical treatment response in 30 RRMS patients, prospectively followed by blinded investigators.

PMID:: 17884184; [PubMed - indexed for MEDLINE]

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Cited by 3 PubMed Central articles

Excessive biologic response to IFNβ is associated with poor treatment response in patients with multiple sclerosis. [PLoS One. 2011]
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