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Arch Dis Child. 2008 Mar;93(3):251-4. Epub 2007 Sep 19.

Investigation and management of coeliac disease.

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  • 1Department of Paediatric Gastroenterology, Children's Hospital for Wales, Cardiff, UK.


Coeliac disease (CD) is common in children with an estimated prevalence of approximately 1:100. The clinical presentation has altered over the last decade, with most children manifesting non-specific or mild symptoms. The accuracy of serological testing has improved dramatically with targeted assessment of children with conditions known to be associated with CD leading to the detection of asymptomatic cases. The diagnosis of CD still requires upper gastrointestinal endoscopy and small bowel biopsy, and management requires a life-long gluten-free diet to avoid long-term complications.

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