Send to:

Choose Destination
See comment in PubMed Commons below
J Cardiovasc Med (Hagerstown). 2007 Sep;8 Suppl 1:S38-41.

Mediterranean diet and n-3 fatty acids in the prevention and treatment of cardiovascular disease.

Author information

  • 1PRETA-TIMC, Equipe Coeur & Nutrition, CNRS UMR 5525-UJF-INP, University Joseph Fourier, Grenoble, France.


Consumption of a traditional Mediterranean diet and n-3 polyunsaturated fatty acids (PUFAs) was shown to be effective in reducing the complications of coronary heart disease in randomised controlled trials. Epidemiological studies and controlled trials indicate that plant- and sea-derived n-3 PUFAs are likely to be important mediators of the protection provided by traditional Mediterranean diets. Of note, consumption of marine n-3 PUFAs from fish and other seafood is high in certain Mediterranean countries (Spain, Portugal), but quite low in others (Italy, Greece). A relative insufficiency of dietary marine n-3 PUFAs among Italians might in part explain the results of the GISSI-Prevenzione trial, in which a modest supplementation of eicosapentaenoic acid + docosahexaenoic acid ( approximately 850 mg/day) produced striking reductions in coronary heart disease death (-30%) and sudden cardiac death (-45%) among patients with known heart disease. The protection provided by n-3 PUFAs from both plant and marine sources may be partly dependent on other dietary factors. Plant and marine n-3 PUFAs are likely to be major mediators of the protective effect provided by traditional Mediterranean diets.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk