Antimicrob Agents Chemother. 2007 Dec;51(12):4484-5. Epub 2007 Sep 17.

Intrinsic novobiocin resistance in Staphylococcus saprophyticus.

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Antimicrobial Research Centre and Research Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.

Abstract

Intrinsic novobiocin resistance in Staphylococcus saprophyticus was associated with expression of a novobiocin-resistant form of the drug target protein (GyrB). Site-directed mutagenesis established that resistance depends upon the presence of two specific amino acid residues in GyrB: a glycine at position 85 and a lysine at position 140.

PMID:: 17876001; [PubMed - indexed for MEDLINE]
PMCID:: PMC2167987

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