Send to

Choose Destination
See comment in PubMed Commons below
Stem Cell Rev. 2007 Jun;3(2):176-82.

Breast cancer stem cells-research opportunities utilizing mathematical modeling.

Author information

  • 1Department of Mathematics, University of Michigan, 530 Church St., Ann Arbor, MI 48109, USA.


There is increasing evidence for the "cancer stem cell hypothesis" which holds that cancers originate in tissue stem cells or progenitor cells. As a result of this, cancers are driven by a cellular subcomponent that retains stem cell properties. Among these properties are self-renewal and multi-lineage differentiation. The biological processes which account for stem cell properties are currently being elucidated. Cancer stem cells maintain many of the same characteristics of their normal counterparts. The combination of biological research with mathematical modeling may provide for a greater understanding of the complex picture of breast cancer stem cells and assist cancer biologists and clinical oncologists in designing and testing novel therapeutic strategies.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk