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J Antimicrob Chemother. 2007 Nov;60(5):999-1003. Epub 2007 Sep 14.

Comparative activity of pradofloxacin against anaerobic bacteria isolated from dogs and cats.

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  • 1MB Consult Limited, Lymington, SO41 3TQ, UK. p-s@mbconsult.co.uk

Abstract

OBJECTIVES:

To compare the intrinsic activity of pradofloxacin, a new fluoroquinolone developed for use in veterinary medicine, with other fluoroquinolones, against anaerobic bacteria isolated from dogs and cats.

METHODS:

One hundred and forty-one anaerobes were isolated from dogs and cats and comparative MICs of pradofloxacin, marbofloxacin, enrofloxacin, difloxacin and ibafloxacin were determined according to standardized agar dilution methodology.

RESULTS:

Pradofloxacin exerted the greatest antibacterial activity followed by marbofloxacin, enrofloxacin, difloxacin and ibafloxacin. Based on the distinctly lower MIC(50), MIC(90) and mode MIC values, pradofloxacin exhibited a higher in vitro activity than any of the comparator fluoroquinolones.

CONCLUSIONS:

Pradofloxacin, a novel third-generation fluoroquinolone, has broad-spectrum anti-anaerobe activity and offers utility as single-drug therapy for mixed aerobic/anaerobic infections.

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