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Immunol Allergy Clin North Am. 2007 Aug;27(3):357-75.

Mechanisms of eosinophilia in the pathogenesis of hypereosinophilic disorders.

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  • 1Department of Biochemistry and Molecular Genetics (M/C 669), Molecular Biology Research Building, Rm. 2074, 900 S. Ashland Avenue, The University of Illinois at Chicago College of Medicine, Chicago, IL 60607, USA.


The increased numbers of activated eosinophils in the blood and tissues that typically accompany hypereosinophilic disorders result from a variety of mechanisms. Exciting advances in translating discoveries achieved from mouse models and molecular strategies to the clinic have led to a flurry of new therapeutics specifically designed to target eosinophil-associated diseases. So far, this form of hypothesis testing in humans in vivo through pharmacology generally has supported the paradigms generated in vitro and in animal models, raising hopes that a spectrum of novel therapies soon may become available to help those who have eosinophil-associated diseases.

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