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Hum Psychopharmacol. 2007 Dec;22(8):515-28.

Retrospective database analysis on the effectiveness of typical and atypical antipsychotic drugs in an outpatient clinic setting.

Author information

  • 1Medical Faculty, Psychiatry Department, Uludag University, Bursa, Turkey. cakkaya@uludag.edu.tr

Abstract

OBJECTIVE:

To report the outcomes of a retrospective database analysis to compare the effectiveness of atypical and typical antipsychotic drugs.

METHODS:

Medical records of patients admitted to the psychiatry outpatient clinic between January 1998 and October 2005 were retrospectively reviewed. Data obtained from patient records were noted on a special form assessing four aspects of the treatment history: socio-demographic features, disease characteristics, initial treatment at the time of admission, and course of treatment. Patient groups (typical/atypical and Risperidone/Haloperidol/Olanzapine) were compared for time to all-cause medication discontinuation and rate of discontinuation.

RESULTS:

There was no statistically significant difference in the duration of treatment between patients using atypical (n = 150) and typical (n = 124) antipsychotics. The duration of treatment was significantly longer in patients on Haloperidol (n = 91) compared with those on Risperidone (n = 63). Rates of discontinuation over 18 months were 59.3% for patients on atypical antipsychotics and 57.3% for those on typical antipsychotics, and 68.3% for patients on Risperidone, 51.6% for patients on Haloperidol and 54.3% for patients on Olanzapine.

CONCLUSION:

Despite our hypothesis patients with chronic schizophrenia discontinued their atypical and typical antipsychotics, at a high rate with no significant difference indicating substantial limitations in the effectiveness of these drugs.

PMID:
17868197
[PubMed - indexed for MEDLINE]
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