Org Lett. 2007 Oct 11;9(21):4319-22. Epub 2007 Sep 15.

A nonacid degradable linker for solid-phase synthesis.

Colombo A, De la Figuera N, Fernàndez JC, Fernández-Forner D, Albericio F, Forns P.

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Almirall-Barcelona Science Park Unit, Josep Samitier 1-5, E-08028 Barcelona, Spain.

Abstract

Synthesis and applications of two new nonacid degradable linkers as an alternative to the Wang linker for solid-phase synthesis are described. Resin from linker 2 looks superior to linker 1 in terms of yields for both anchoring of the first building block and cleavage and in terms of higher purity of the final product. Use of linker 2 avoids side reactions associated with the use of Wang resin due to an undesired cleavage during final acid treatment.

PMID:: 17867699; [PubMed - indexed for MEDLINE]

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