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J Dermatolog Treat. 2007;18(5):286-90.

A comparison of two cyclosporine dosage regimens for the treatment of severe psoriasis.

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  • 1Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND:

Few reports have been issued which compare the efficacy and tolerability of cyclosporine dose adjustments before 12 weeks of treatment.

OBJECTIVE:

To compare the efficacy and tolerability of two different dosage regimens of cyclosporine in severe psoriasis.

METHODS:

This 12-week, prospective, open-label study included 61 severe psoriasis patients. Patients were assigned to a 2.5 mg/kg per day starting dose and an increasing regimen ('standard regimen') or a 5.0 mg/kg per day starting dose and a decreasing regimen ('step-down regimen') group. The end point included 50% and 75% reductions in Psoriasis Area and Severity Index (PASI) scores. Adverse events were also evaluated.

RESULTS:

According to a 50% PASI reduction (PASI 50), the response rate at 12 weeks was similar for two groups. The percentage of patients achieving a 75% PASI reduction (PASI 75) at 12 weeks was higher in the step-down regimen group. The mean time to PASI 50 or PASI 75 was shorter in the step-down regimen group. No difference was found between the two groups in terms of the number of patients with adverse events requiring intervention.

CONCLUSION:

This study suggests that the 'step-down' cyclosporine regimen offers an effective and safe therapeutic option for the management of severe psoriasis.

PMID:
17852632
[PubMed - indexed for MEDLINE]
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