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Trends Cell Biol. 2007 Oct;17(10):511-7. Epub 2007 Sep 11.

Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics.

Author information

  • 1Department Biomedical Sciences, University of Padua, Viale G. Colombo 3, 35121 Padua, Italy. paola.pizzo@unipd.it

Abstract

Mitochondria and endoplasmic reticulum (ER) have different roles in living cells but they interact both physically and functionally. A key aspect of the mitochondria-ER relationship is the modulation of Ca(2+) signaling during cell activation, which thus affects a variety of physiological processes. We focus here on the molecular aspects that control the dynamics of the organelle-organelle interaction and their relationship with Ca(2+) signals, also discussing the consequences that these phenomena have, not only for cell physiology but also in the control of cell death.

PMID:
17851078
[PubMed - indexed for MEDLINE]
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