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    BMC Cancer. 2007 Sep 11;7:175.

    TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study.

    Cox DG, Penney K, Guo Q, Hankinson SE, Hunter DJ.

    Source

    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, USA. dcox@hsph.harvard.edu

    Abstract

    BACKGROUND:

    Transforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter. Single nucleotide polymorphisms in TGFB1 and a microsatellite in TGFBR1 have been investigated for association with risk of breast cancer, with conflicting results.

    METHODS:

    We examined polymorphisms in the promoter region of the TGFB1 gene as well as the TGFBR1*6A microsatellite in the Nurses' Health Study cohort.

    RESULTS:

    No overall associations between the L10P polymorphism of TGFB1 or the TGFBR1 microsatellite were detected. However, we observed an inverse association between the -509 C/T polymorphism of TGFB1 (p-trend = 0.04), which was stronger and more significant among women with estrogen receptor positive breast cancer.

    CONCLUSION:

    Polymorphisms in the promoter region of TGFB1 are not likely to be associated with large increases in breast cancer risk overall among Caucasian women.

    PMID:
    17848193
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2082040
    Free PMC Article

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