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BMC Cancer. 2007 Sep 11;7:175.

TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study.

Author information

  • 1Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, USA. dcox@hsph.harvard.edu

Abstract

BACKGROUND:

Transforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter. Single nucleotide polymorphisms in TGFB1 and a microsatellite in TGFBR1 have been investigated for association with risk of breast cancer, with conflicting results.

METHODS:

We examined polymorphisms in the promoter region of the TGFB1 gene as well as the TGFBR1*6A microsatellite in the Nurses' Health Study cohort.

RESULTS:

No overall associations between the L10P polymorphism of TGFB1 or the TGFBR1 microsatellite were detected. However, we observed an inverse association between the -509 C/T polymorphism of TGFB1 (p-trend = 0.04), which was stronger and more significant among women with estrogen receptor positive breast cancer.

CONCLUSION:

Polymorphisms in the promoter region of TGFB1 are not likely to be associated with large increases in breast cancer risk overall among Caucasian women.

PMID:
17848193
[PubMed - indexed for MEDLINE]
PMCID:
PMC2082040
Free PMC Article

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