- Erratum in:
- Am J Hum Genet. 2008 Jan;82(1):251.
Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
Tan Z,
Randall G,
Fan J,
Camoretti-Mercado B,
Brockman-Schneider R,
Pan L,
Solway J,
Gern JE,
Lemanske RF,
Nicolae D,
Ober C.
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. tzheng@bsd.uchicago.edu
HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.
PMID: 17847008 [PubMed - indexed for MEDLINE]
PMCID: PMC2227932