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    J Heart Lung Transplant. 2007 Sep;26(9):944-52.

    Epstein-Barr virus-associated multifocal leiomyosarcomas arising in a cardiac transplant recipient: autopsy case report and review of the literature.

    Source

    Department of Pathology, Heart Failure and Transplant Service, New York Medical College at Westchester Medical Center, Valhalla, New York, USA.

    Abstract

    Epstein-Barr virus (EBV) associated smooth muscle tumors (SMTs) have been described in patients with acquired immune deficiency syndrome (AIDS) and, more recently, in association with immunosuppression after solid-organ transplantation. We present the autopsy findings of multiple leiomyosarcomas (LMSs) in a 24-year old man who died 18 months after undergoing orthotopic cardiac transplantation for idiopathic cardiomyopathy. The recognition of EBV-driven LMS developing in cardiac transplant recipients in multiple unusual sites is crucial for the management of these patients and should include complete surgical removal anti-viral therapy and modulation of immunosuppression.

    PMID:
    17845934
    [PubMed - indexed for MEDLINE]

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