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Genome Biol. 2007;8(9):R186.

Coverage and error models of protein-protein interaction data by directed graph analysis.

Author information

  • 1EMBL, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. tchiang@ebi.ac.uk

Abstract

Using a directed graph model for bait to prey systems and a multinomial error model, we assessed the error statistics in all published large-scale datasets for Saccharomyces cerevisiae and characterized them by three traits: the set of tested interactions, artifacts that lead to false-positive or false-negative observations, and estimates of the stochastic error rates that affect the data. These traits provide a prerequisite for the estimation of the protein interactome and its modules.

PMID:
17845715
[PubMed - indexed for MEDLINE]
PMCID:
PMC2375024
Free PMC Article

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