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Allergy. 2007 Oct;62(10):1199-204.

Association between obesity and asthma in a twin cohort.

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  • 1Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark.

Abstract

BACKGROUND:

Obesity is linked to asthma in a yet poorly understood manner. We examined the relationship between obesity and asthma in a population-based sample of twins.

METHODS:

From the cohorts born between 1953 and 1982, who were enrolled in The Danish Twin Registry, a total of 29 183 twin individuals participated in a nationwide questionnaire study, where data on height, weight and asthma were collected. Latent factor models of genetic and environmental effects were fitted using maximum likelihood methods.

RESULTS:

The age-adjusted risk of asthma was increased both in obese females, OR = 1.96 (1.45-2.64), P < or = 0.001 and in obese males, OR = 1.59 (1.08-2.33), P = 0.02. According to best-fitting models, the heritability for obesity was 81% in males and 92% in females, whereas the heritability for asthma was 78% and 68% in males and females respectively. The age-adjusted genetic liabilities to obesity and asthma were significantly correlated only in females, r = 0.28 (0.16-0.38).

CONCLUSIONS:

Obese subjects have an increased risk for asthma, which in females seems partly because of common genes.

[PubMed - indexed for MEDLINE]
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