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Neurochem Res. 1991 Sep;16(9):1055-8.

Fluoroacetate and fluorocitrate: mechanism of action.

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  • 1Department of Chemistry, Fordham University, Bronx, NY 10458.

Abstract

The concept of lethal synthesis as suggested by Peters is reviewed in the light of the more recent work in this area. It is suggested that fluorocitrate is a "suicide" substrate for aconitase rather than a competitive inhibitor as originally suggested. The use of these substances to study glial-neuronal relationships is considered.

PMID:
1784332
[PubMed - indexed for MEDLINE]
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