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Mol Cell Biochem. 2008 Jan;307(1-2):141-7. Epub 2007 Sep 9.

NF-kappaB controls growth of glioblastomas/astrocytomas.

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  • 1Department of Biological Sciences, Western Michigan University, Kalamazoo, MI 49008, USA.


NF-kappaB is a family of transcription factors that have been shown to be elevated in a variety of tumor types and in some cases central to their survival and growth. Here we present evidence that U-87 MG and U-118 MG growth is regulated by NF-kappaB and controlled by PDGF. NF-kappaB activity was suppressed by a dominant negative mutant of the human PDGF type beta receptor and PDGF-B chain neutralizing antibodies. Creation of cell lines that had inducible expression of shRNAs directed against either c-Rel or RelA inhibited growth almost 90% indicating that NF-kappaB plays a central role in glioblastoma growth.

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