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Am J Obstet Gynecol. 2007 Sep;197(3):244.e1-8.

Angiogenic factors for the prediction of preeclampsia in high-risk women.

Author information

  • 1Department of Obstetrics and Gynecology, University of Massachusetts Medical School/UMass Memorial Health Care, Worcester, MA 01605, USA. mooret@ummhc.org

Abstract

OBJECTIVE:

The objective of the study was to evaluate angiogenic factors for the prediction of preeclampsia in high-risk women.

STUDY DESIGN:

We collected serial serum specimens from 94 women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 (sFlt1) and placental growth factor (PlGF) were measured by enzyme-linked immunosorbent assay.

RESULTS:

Mean serum sFlt1 and the sFlt1/PlGF ratio were higher in subjects who developed early-onset (less than 34 weeks) preeclampsia, as compared with subjects without preeclampsia, from 22 weeks gestation onward. In subjects who developed late-onset (34 weeks or later) preeclampsia, sFlt1 was significantly increased after 31 weeks' gestation. The sFlt1/PlGF ratio at 22-26 weeks was highly predictive of early-onset preeclampsia. The within-woman rate of change of the sFlt1/PlGF ratio was predictive of overall preeclampsia risk.

CONCLUSIONS:

In high-risk women, serum sFlt1 and the sFlt1:PlGF ratio are altered prior to preeclampsia onset and may be predictive of preeclampsia. Larger studies are needed to confirm these findings.

PMID:
17826405
[PubMed - indexed for MEDLINE]
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