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Trends Plant Sci. 2007 Oct;12(10):465-73. Epub 2007 Sep 10.

Tête-à-tête: the function of FKBPs in plant development.

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  • 1Zurich-Basel Plant Science Center, University of Zurich, Institute of Plant Biology, Zolliker Strasse 108, CH-8008 Zurich, Switzerland. markus.geisler@botinst.uzh.ch


Compared with that of other eukaryotes, the nuclear genome of the model plant Arabidopsis thaliana encodes an expanded family of FK506-binding proteins (FKBPs). Whereas approximately half of the FKBPs are implicated in the regulation of photosynthetic processes, a subcluster appears to be stress responsive. Recent reports indicate that a discrete group of Arabidopsis multidomain FKBPs regulate plant hormone pathways by recruiting or modulating client proteins via direct protein-protein interactions (tête-à-tête). This suggests that multidomain FKBPs function as central elements in plant development by linking hormone responses with other signal transduction pathways. Here, we present a summary of current research demonstrating that, in addition to their role in protein folding, subsets of plant FKBPs exhibit diverse functionality.

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