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    Bioorg Med Chem Lett. 2007 Oct 15;17(20):5506-9. Epub 2007 Aug 29.

    Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities.

    Peng W, Tang P, Hu X, Liu JO, Yu B.

    State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

    The A,B-ring-truncated OSW saponin analogs (1, 18a, and 18b) were synthesized. These greatly simplified trans-hydrindane disaccharides retained considerable inhibitory activity against the growth of HeLa and Jurkat T cells (IC(50)=0.8-21.1 microM).

    PMID: 17826089 [PubMed - indexed for MEDLINE]

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