Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Oral Oncol. 2008 Jan;44(1):10-22. Epub 2007 Sep 6.

Critical evaluation of diagnostic aids for the detection of oral cancer.

Author information

  • 1Department of Pathology, The University of Chicago, Pritzker School of Medicine, 5841 S. Maryland Avenue, Chicago, IL 60637, USA. mark.lingen@uchospitals.edu

Abstract

Historically, the screening of patients for signs of oral cancer and precancerous lesions has relied upon the conventional oral examination. A variety of commercial diagnostic aids and adjunctive techniques are available to potentially assist in the screening of healthy patients for evidence of otherwise occult cancerous change or to assess the biologic potential of clinically abnormal mucosal lesions. This manuscript systematically and critically examines the literature associated with current oral cancer screening and case-finding aids or adjuncts such as toluidine blue, brush cytology, tissue reflectance and autofluorescence. The characteristics of an ideal screening test are outlined and the authors pose several questions for clinicians and scientists to consider in the evaluation of current and future studies of oral cancer detection and diagnosis. Although the increased public awareness of oral cancer made possible by the marketing of recently-introduced screening adjuncts is commendable, the tantalizing implication that such technologies may improve detection of oral cancers and precancers beyond conventional oral examination alone has yet to be rigorously confirmed.

Comment in

PMID:
17825602
[PubMed - indexed for MEDLINE]
PMCID:
PMC2424250
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk